Medicinal plants with promising antileishmanial activity in Iran: a systematic review and meta-analysis
نویسندگان
چکیده
BACKGROUND Leishmaniasis is a major public health problem worldwide. The aim of the present study was to investigate medicinal plants with anti-Leishmania activity which used in Iran. METHODS Data were systematically gathered from five English databases including Ebsco, Science Direct, PubMed, Google Scholar and Scopus, four Persian databases including Magiran, Iran doc, Iran medex and the Scientific Information Database (SID) from 1999 to April 2015. Information obtained included plant family, extraction method, concentrations of extracts, animal models and parasite strains. RESULTS A total of 68 articles including 188 experiments (140 in vitro and 48 in vivo) between 1999 and 2015, met our eligibility criteria. Thoroughly, 98 types of plants were examined against three genera of Leishmania spp. For the heterogeneity study conducted, it was showed that there was a great deal of variation among studies. Based on random effect, meta-analysis pooled mean of IC50 was obtained 456.64 (95% CI: 396.15, 517.12). CONCLUSION The most Iranian plants used as anti-leishmanial activity were Artemisia species, Allium sativum, Achilleamille folium, Peganum harmala and Thymus vulgaris. The present systematic and meta-analysis review provide valuable information about natural products with anti-Leishmania activity, which would be examined in the future experimental and clinical trials and herbal combination therapy.
منابع مشابه
Medicinal Plants With Antileishmanial Properties: A Review Study
Background: Leishmaniasis is an infectious disease caused by various species of the Leishmania parasites. An effective vaccine or drug to prevent the infestation or a suitable medication to cure the disease without side effects has not been provided yet. Objectives: The use of medicinal herbs in the treatment of many diseases, especially parasitic ones, dates back to prehistoric times. This a...
متن کاملEffective materials of medicinal plants for leishmania treatment in vivo environment
Background: Treatment of leishmaniasis is a challenge due to problems such as high price and dose of the drug, drug resistance and side effects. Objective: The study aims to introduce plants compounds, which their antileishmanial effects were approved in vivo conditions. Methods: This study as a review article was performed by searching the keywords of “medicinal plants with in vivo antileishma...
متن کاملEffect of pentoxifylline on anemia in patients with chronic kidney disease: an updated systematic review and meta-analysis
Background: Pentoxifylline, a valuable medication with promising clinical characteristics and considerable profile of safety is used in many conditions namely chronic kidney diseases (CKD). However, the decision to prescribe pentoxifylline for anemia in CKD should be based on evidence accrued from randomized controlled trials (RCTs). Yet, substantial heterogeneity exists in studies performed to...
متن کاملA Systematic Review and Meta-Analysis on the Effect of Cotoneaster manna on Neonatal Jaundice
Background & Aim: The manna of Cotoneaster nummularia (purgative manna) has been traditionally used in the Persian medicine for the treatment of neonatal jaundice. The effect of Cotoneaster manna on neonatal jaundice was investigated with systematic review and meta-analysis. Experimental: This study intended to explore the clinical trial...
متن کاملA Systematic Review and Meta-Analysis on the Effect of Cotoneaster manna on Neonatal Jaundice
Background & Aim: The manna of Cotoneaster nummularia (purgative manna) has been traditionally used in the Persian medicine for the treatment of neonatal jaundice. The effect of Cotoneaster manna on neonatal jaundice was investigated with systematic review and meta-analysis. Experimental: This study intended to explore the clinical trial...
متن کامل